Understanding
Okur-Chung Neurodevelopmental Syndrome
CK2 substrates focused on the brain
CK2 substrates – Brain
This resource was generated by Heike Rebholz, PhD, and members of her lab, Demetra Ballardin and Barbara Lecis.
| Name of protein | Phosphosite/s (h=human m=mouse sequence) | In vitro | In vivo/ex vivo (brain tissue if known) | Function | Ref |
|---|---|---|---|---|---|
| NMDAR N2b | pS1480 (m) (r) | Rat cortical and hypothalamic cultured neurons, Rat hippocampal membrane homogenates | Disrupts its association with PDZ domain-containing proteins and drives NR2B-endocytosis | Chung 2004, Sanz-Clemente 2010, Ye 2012 | |
| PTEN | pS370/pS380/S382/pS383/S385 | Hela cells | PTEN stabilization and turnover | Torres and Pulido, 2001 | |
| Darpp-32 | pS97 (m) (rat) | rat striatum | Activates DARPP-32 + induces translocation to nucleus and of pHisH3 | Girault 1989 | |
| Akt | pS129 | Jurkat, LNCaP cell line, HEK 293T cells | Rat (hippocampus) stereotaxically transfected with plasmids | increase in Akt catalytic activity | Di Maira 2005, Chao 2007 (Chao paper in contradiction to others) |
| a-synuclein | pS129 | In vitro | Sano 2021 doi.org/10.1186/s40478-021-01281-9 | ||
| Topoisomerase IIa | pS1469 (h) | Hela S3 cells | Chromatin condensation during prophase | Escargueil 2000 | |
| Olig2 | Developing mouse brain | Xu 2020, Huillard 2010 | |||
| Calmodulin | pT79 | In vitro, P is inhibited CK2b and enhanced by polybasic peptides. | Alters the interaction with downstream effectors (CamKII, NOS…) | Meggio 1992, Arrigoni 2004 | |
| Muscarinic M3 acetylcholine receptor | Induce switch to a Jun-kinase dependent pathway | Torrecilla 2007 | |||
| GluA1 | pS567/S579 | Hippocampal neurons | Cell surface accumulation of GluA1 | Lussier 2014 | |
| Synaptotagmin I | pT128 (bovine) | Solubilized bovine brain membranes and total brain homogenate | modulation of its Ca2+ binding properties | Davletov 1993, Bennet 1993 | |
| Syntaxin | pS14 | Rat brain homogenates and brain slices (p5) | modulation of exocytosis/ involved in the distinction between active zones and nonsynaptic axonal membrane? | Littleton 1995, Foletti 2000 | |
| Dynamin1 | In vitro | prevents phosphorylation by PKC | Robinson 1993 | ||
| voltage gated sodium channel NAv1 | pS1112 | Rat hippocampal neurons | Enhancing its binding to ankyrin and accumulation at the axon initial segment + regulates CK2 accumulation in AIS | Hien 2014 | |
| Hsp90/Cdc37 + FKBP51-2 | Essential for chaperone function + increases or reduces Tau stability | Miyata 2009, Storer 2011 | |||
| Nrf1 | In vitro | Modulate the expression of proteasome genes | Tsuchiya 2013 | ||
| IκBα | |||||
| NFκB p65 | pS529 | In vitro | Increases NFkB transcriptional activity | Dan Wang 2000 |