Project: Drug repurposing screen using OCNDS Fly Model

Clement received his BA from Cornell University in 2003. He completed his Ph.D. in 2008 in the Department of Human Genetics at the University of Michigan, where he worked with Miriam Meisler. Clement completed his postdoctoral training as a co-mentored postdoc with Andy Clark and Mariana Wolfner at Cornell University. While not in the lab, he is wrangling two unruly children and four chickens.

About the Chow lab:

Our lab is focused on understanding the role of genetic variation on disease outcomes. We employ quantitative and functional tools, in a variety of model organisms, to study how genetic variation impacts basic cellular traits important to human health. Our work in model organisms will help to model and inform studies of genetic variation in the human population. We hope to identify variations that can lead to more precise, personalized therapies, especially for rare disease.

Grant Details:

Project funded for 1 year starting in 2024 for a total of $72,877.07.

Aims of Grant:

Dr. Chow will utilize the Prestwick Chemical Library consisting of 1,520 compounds using a fly model of OCNDS where the CK2 protein is reduced. Using the fly eye structure as a readout of drug effects, his lab will generate a list of ‘hits’ (compounds) that improve the fly’s symptoms. This means that we have a compiled list of compounds that we can test across other OCNDS models and potentially, test quickly in patients to help improve various symptoms.